1 Animal World Notophthalmus viridescens limbs evolved organ regeneration Thu Dec 05, 2013 12:34 am
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Amphibians unique protein expression showed that if we have the potential to regenerate is still unknown.
It is generally believed that the ability to regenerate organs ancient animal trait of all multicellular animals have. However , genetic analysis showed that of the salamander , the ability to appear and this time not so long ago .
Red dot newt (Notophthalmus viridescens) although very small, but it was far more than the ability to regenerate those organs most advanced biotechnology laboratories . This salamander can regenerate lost organs, including the heart , central nervous system, component , or even the eye's lens .
Doctors hope that despite this ability is based on a potential , but for all animals ( including mammals ) are prevalent genetic basis of the program , so that it can be applied to regenerative medicine . For example, the mouse can generate new heart cells after myocardial injury.
However , Bad Nauheim , Germany 's Max Planck Institute for cardiopulmonary Thomas Brown (Thomas Braun) and research colleagues has shown that this is far from simple.
Find salamander in the study of human , mouse and Drosophila same genetic mechanism had stalled because the salamander genome is very large, more than ten times the human genome . Thus, Brown and colleagues examined the resulting gene expression when Newt RNA ( called " transcriptome " ) , and the use of the three kinds of analysis techniques to summarize the data .
Team for the first time a summary of the red dot newt (N. viridescens) of all RNA transcripts , check out the salamander embryos and larvae of the heart, limbs and original and eye tissue regeneration .
The researchers found that more than 120,000 RNA transcripts , of which there are about 15,000 of the encoded protein. Among them, there are 826 unique salamander . In addition, the expression of sequences in several organs of the original and the reproduction are different .]
It is generally believed that the ability to regenerate organs ancient animal trait of all multicellular animals have. However , genetic analysis showed that of the salamander , the ability to appear and this time not so long ago .
Red dot newt (Notophthalmus viridescens) although very small, but it was far more than the ability to regenerate those organs most advanced biotechnology laboratories . This salamander can regenerate lost organs, including the heart , central nervous system, component , or even the eye's lens .
Doctors hope that despite this ability is based on a potential , but for all animals ( including mammals ) are prevalent genetic basis of the program , so that it can be applied to regenerative medicine . For example, the mouse can generate new heart cells after myocardial injury.
However , Bad Nauheim , Germany 's Max Planck Institute for cardiopulmonary Thomas Brown (Thomas Braun) and research colleagues has shown that this is far from simple.
Find salamander in the study of human , mouse and Drosophila same genetic mechanism had stalled because the salamander genome is very large, more than ten times the human genome . Thus, Brown and colleagues examined the resulting gene expression when Newt RNA ( called " transcriptome " ) , and the use of the three kinds of analysis techniques to summarize the data .
Team for the first time a summary of the red dot newt (N. viridescens) of all RNA transcripts , check out the salamander embryos and larvae of the heart, limbs and original and eye tissue regeneration .
The researchers found that more than 120,000 RNA transcripts , of which there are about 15,000 of the encoded protein. Among them, there are 826 unique salamander . In addition, the expression of sequences in several organs of the original and the reproduction are different .]